Population
Mammalian models (embryonic and adult hearts, skeletal muscle)
Comparison
Stem cell marker-free, dual… vs Embryonic development vs adult homeostasis vs…
Design
Preclinical
Key result
Dual recombinases-mediated genetic lineage tracing demonstrated that new myocytes arise from nonmyocytes in the embryonic heart, but not in the adult heart during homeostasis or after myocardial infarction.
Authors
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Challenges adult stem cell-based regeneration post-MI; leaves open alternative myocyte sources for future human studies.
In vivo genetic lineage tracing provides evidence against the myogenic potential of putative stem cell populations for cardiac regeneration in the adult mammalian heart.
Li et al. (2018) studied Myocardial infarction and cardiac regeneration. Dual recombinases-mediated genetic lineage tracing vs. Embryonic heart and skeletal muscle (internal controls) was evaluated on Generation of new myocytes from nonmyocytes. Dual recombinases-mediated genetic lineage tracing demonstrated that new myocytes arise from nonmyocytes in the embryonic heart, but not in the adult heart during homeostasis or after myocardial infarction.
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