Key result
Diffuse cardiac myocyte apoptosis mediated by caspase activation is sufficient to cause dilated cardiomyopathy and heart failure, highlighting the essential role of myocyte death and renewal.
Design
Editorial
Authors
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This editorial emphasizes that cardiac homeostasis involves both myocyte death and renewal, challenging the historical dogma that the heart is a terminally differentiated organ.
This editorial emphasizes that cardiac homeostasis involves both myocyte death and renewal, challenging the historical dogma that the heart is a terminally differentiated organ.
Nadal‐Ginard et al. (2003) conducted an editorial in Dilated cardiomyopathy and heart failure. Cardiac myocyte apoptosis was evaluated. Diffuse cardiac myocyte apoptosis mediated by caspase activation is sufficient to cause dilated cardiomyopathy and heart failure, highlighting the essential role of myocyte death and renewal.
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