Population
Vascular endothelium and blood platelets
Comparison
Removal of prostacyclin from the endothelium and… vs Intact endothelium with normal PGI2 levels
Design
Preclinical
Authors
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PGI2 may limit thrombin-induced platelet adherence; hypothesis-generating in this animal model and requires human validation before clinical consideration.
Prostacyclin (PGI2) plays a major role in preventing thrombin-induced platelet adherence to the vascular endothelium.
Hoak et al. (1981) studied this question.
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