January 1, 1995Journal of Veterinary Diagnostic Investigation

African Swine Fever Virus Infection of Skin-Derived Dendritic Cells in Vitro Causes Interference with Subsequent Foot-and-Mouth Disease Virus Infection

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Population

Highly purified skin-derived dendritic cells (SDDCs) isolated from swine skin

Design

Preclinical

Follow-up

Up to 11 hours postinfection

Authors

DGDouglas A. GreggPlum Island Animal Disease Center DSDonald H. SchlaferCornell University CMCharles A. MebusPfizer (United States)

Discussion

Member takes

Implication

Does not yet inform veterinary practice; leaves open in vivo relevance and mechanistic translation.

Structured PICO

Population

Highly purified skin-derived dendritic cells (SDDCs) isolated from swine skin

Intervention

Independent or sequential inoculation with African swine fever virus (ASFV) and foot-and-mouth disease virus (FMDV)

Outcome

Viral infection, replication, and interference (measured by avidin-biotin immunohistochemical staining and transmission electron microscopy)surrogate

In vitro infection of swine skin-derived dendritic cells with African swine fever virus interferes with subsequent foot-and-mouth disease virus infection.

Cite This Study

Gregg et al. (1995) studied this question.

synapsesocial.com/papers/6a86dfb0c026610cc182b6ae https://doi.org/10.1177/104063879500700106

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African Swine Fever Virus Infection of Skin-Derived Dendritic Cells in Vitro Causes Interference with Subsequent Foot-and-Mouth Disease Virus Infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

African Swine Fever Virus Infection of Skin-Derived Dendritic Cells in Vitro Causes Interference with Subsequent Foot-and-Mouth Disease Virus Infection

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider