January 1, 1995Journal of Veterinary Diagnostic InvestigationOpen Access

African Swine Fever Interference with Foot-and-Mouth Disease Infection and Seroconversion in Pigs

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Why the study?

Does initial infection with African swine fever virus prevent subsequent foot-and-mouth disease virus infection and seroconversion in pigs?

Population

Pigs

Comparison

Initial oral infection with African swine fever… vs Contact pigs inoculated with FMDV only

Design

Preclinical

Follow-up

up to 24 days

Authors

DGDouglas A. GreggPlum Island Animal Disease Center CMCharles A. MebusPfizer (United States)DSDonald H. SchlaferCornell University

Discussion

Member takes

Implication

Indicates potential ASFV-FMDV interference in pigs; hypothesis-generating and requires confirmation before any control implications.

Structured PICO

Does initial infection with African swine fever virus prevent subsequent foot-and-mouth disease virus infection and seroconversion in pigs?

Population

Pigs (including 22 infected with highly virulent L-60 ASFV, 34 infected with moderately virulent DR-2 ASFV, a group of larger pigs, and contact pigs)

Intervention

Initial oral infection with African swine fever virus (highly virulent L-60 or moderately virulent DR-2), followed 3 days later by exposure to foot-and-mouth disease virus (FMDV) via tongue inoculation and contact

Comparator

Contact pigs inoculated with FMDV only

Outcome

FMDV infection and seroconversionsurrogate

Initial infection with African swine fever virus provides a remarkably long-lasting, 1-way interference against foot-and-mouth disease virus infection in pigs.

Cite This Study

Gregg et al. (1995) studied this question.

synapsesocial.com/papers/6a86dfb0c026610cc182b6af https://doi.org/10.1177/104063879500700105

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African Swine Fever Interference with Foot-and-Mouth Disease Infection and Seroconversion in Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

African Swine Fever Interference with Foot-and-Mouth Disease Infection and Seroconversion in Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider