What question did this study set out to answer?

To evaluate congenital hypothyroidism screening results in neonates born to mothers with subclinical hypothyroidism and identify maternal and neonatal factors associated with screening recall.

April 6, 2022American Journal of Perinatology

Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

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To evaluate congenital hypothyroidism screening results in neonates born to mothers with subclinical hypothyroidism and identify maternal and neonatal factors associated with screening recall.
Conducted a retrospective cohort study of pregnant woman-newborn pairs with prenatal thyroid function tests and neonatal screening records between 2014 and 2017.
Classified mothers into euthyroidism and subclinical hypothyroidism groups according to prenatal thyroid function test results.
Defined congenital hypothyroidism screening results using neonatal thyroid-stimulating hormone (TSH) cutoffs of <5.5 mIU/L for normal and ≥5.5 mIU/L for recall.
Neonates of mothers with subclinical hypothyroidism had a significantly higher screening recall rate compared to those born to euthyroid mothers (p < 0.05).
Maternal TSH concentrations above the 97.5th percentile and cesarean delivery significantly increased the risk of neonatal screening recall.
Infant birth characteristics including low birth weight and large for gestational age status were also associated with an increased likelihood of screening recall.

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Implication

Retrospective cohort study reveals elevated congenital hypothyroidism screening recall rates among infants born to mothers with subclinical hypothyroidism, highlighting perinatal risk factors.

Cite This Study

Korkut et al. (2022) studied this question.

synapsesocial.com/papers/6a86e19bbb0787ff27ca0e26 https://doi.org/10.1055/a-1819-1669

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Implication

Retrospective cohort study reveals elevated congenital hypothyroidism screening recall rates among infants born to mothers with subclinical hypothyroidism, highlighting perinatal risk factors.

Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

Effect of Maternal Subclinical Hypothyroidism on Congenital Hypothyroidism Screening Results: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

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