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A practical and sustainable chemical process for the synthesis of highly substituted aldol<-->lactol products was achieved for the first time through the asymmetric Barbas-List aldol (BLA) reaction of 2-hydroxybenzaldehydes with acetone in the presence of a catalytic amount of trans-4-OH-L-proline (see scheme).
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Ramachary et al. (2009) studied this question.
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