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High Resolution Image Download MS PowerPoint Slide A challenging step in the preparation of tetrahydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor. This step typically affords a mixture of products, which requires extensive purification to obtain any pure products. We report the development of two continuous-flow protocols for the preparation of (−)- trans -Δ 9 -tetrahydrocannabinol and (−)- trans -Δ 8 -tetrahydrocannabinol.
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Bassetti et al. (2023) studied this question.
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