Key result
A 9-week-old male Crl:CD(SD) rat that died unexpectedly was diagnosed with spontaneous cardiac hypertrophy, marking the first reported case in this strain.
Case Report (n=1)
No
This is the first reported case of spontaneous cardiac hypertrophy in a Crl:CD(SD) rat, highlighting a rare background lesion in this strain.
Alerts to rare spontaneous cardiac hypertrophy in young CD(SD) rats; leaves open its prevalence and relevance to preclinical cardiac safety studies.
Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated cardiac enlargement with thickening of the right and left ventricular walls. Histopathological examination revealed hypertrophy of the cardiomyocytes in the right and left ventricular walls and the interventricular septum. Electron microscopic examination indicated bizarre nuclei and accumulation of an increased number of various sizes of mitochondria in the perinuclear region of the hypertrophied myocytes. Hypertrophied myocytes connected by intensely folded intercalated disks were also observed. Based on these findings, the animal was diagnosed with cardiac hypertrophy. This is the first case report of cardiac hypertrophy in this strain.
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Suzuki et al. (2009) conducted a case report in Spontaneous cardiac hypertrophy (n=1). Spontaneous cardiac hypertrophy vs. Normal SD rats was evaluated on Heart weight and histopathological evidence of cardiac hypertrophy. A 9-week-old male Crl:CD(SD) rat that died unexpectedly was diagnosed with spontaneous cardiac hypertrophy, marking the first reported case in this strain.
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