Rhodium‐Catalyzed Asymmetric Addition of Aryl‐ and Alkenylboronic Acids to Isatins

Mopping up the rhodium: A rhodium-catalyzed asymmetric addition of arylboronic acids to isatins has been developed to produce biologically relevant 3-aryl-3-hydroxy-2-oxindoles in high yield (see scheme). High enantioselectivity was observed with (R)-MeO-mop as a ligand, and the reaction could be extended to the addition of alkenyl groups.