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Direct asymmetric aldol reactions at the less substituted carbon atom of unmodified unsymmetrical ketones are achieved in the presence of the commercially available aldolase I antibody 84G3 [Eq. (1)]. All the reactions proceeded with enantiomeric excesses greater than 94 %. Both enantiomers are accessible by using either an aldol or a retro-aldol reaction.
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Maggiotti et al. (2002) studied this question.
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