Key result
Administration of three-factor prothrombin complex concentrate (PCC3) alone successfully managed active left gluteal arterial extravasation in a patient on apixaban.
Why the study?
Does three-factor prothrombin complex concentrate (PCC3) alone successfully manage active bleeding associated with apixaban?
Case Report (n=1)
Does three-factor prothrombin complex concentrate (PCC3) alone successfully manage active bleeding associated with apixaban?
Administration of three-factor prothrombin complex concentrate (PCC3) alone may be effective for reversing apixaban-associated major bleeding without the volume overload risk of fresh frozen plasma.
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May support PCC3 consideration in apixaban bleeding; hypothesis-generating case report requiring prospective trials before practice change.
Denetclaw et al. (2015) conducted a case report in Apixaban-associated bleeding (n=1). Three-factor prothrombin complex concentrate (PCC3) was evaluated on Management of active bleeding. Administration of three-factor prothrombin complex concentrate (PCC3) alone successfully managed active left gluteal arterial extravasation in a patient on apixaban.
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