Key result
The combination of moderate swimming exercise and vitamin D3 supplementation significantly increased adipose tissue SIRT1 protein levels (23.38 vs 10.11 ng/mg, p<0.001) in high-fat diet-induced obese rats.
Why the study?
Obesity causes metabolic dysfunctions, prompting the evaluation of moderate exercise and vitamin D3 on adipose tissue SIRT1 protein level in obese rats.
Does moderate exercise and vitamin D3 supplementation increase adipose tissue SIRT1 protein and improve anthropometric parameters in high-fat diet-induced obese rats?
Does moderate exercise and vitamin D3 supplementation increase adipose tissue SIRT1 protein and improve anthropometric parameters in high-fat diet-induced obese rats?
Absolute Event Rate: 23.38% vs 10.11%
p-value: p=<0.001
The combination of moderate exercise and vitamin D3 supplementation significantly improves anthropometric parameters and increases adipose tissue SIRT1 protein levels in a rat model of high-fat diet-induced obesity.
May increase adipose SIRT1 with combined exercise plus vitamin D3 in obese rats; leaves open clinical translation.
Aims: Obesity is a chronic metabolic disease affecting almost all physiological functions of the body leading to increased morbidity and mortality.The increased prevalence of obesity has been attributed to several risk factors that contribute to several metabolic dysfunctions.This study was conducted to evaluate the effect of moderate exercise and vitamin D3 on adipose tissue SIRT1 protein level in obese rats.Material and Methods: The study was carried out on 40 adult male Wister albino rats, divided into Group 1 (control group): 8 rats received a standard rat diet for 12 weeks and Group 2 (obese group): 32 rats received a high fat diet (HFD) for 4 weeks.Group 2 was further subdivided into 4 subgroups each of 8 rats; (a) Control sedentary group (b) Exercise group (c) Vitamin D3 supplement group (d) Exercise plus vitamin D3 supplement group.At the end of 12 weeks, the anthropometric index and adipose tissue SIRT1 protein by ELISA were measured.Results: HFD results in abnormal anthropometric data and a significant reduction of SIRT1 protein in adipose tissue.In addition to elevation of SIRT1 protein in combined treatment, there was a negative correlation between SIRT1 protein and adiposity index.Discussion: The combination of VD and exercise improved significantly anthropometric parameters and increased adipose tissue SIRT1 protein.
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Abdulrraziq et al. (2024) studied Obesity (n=40). Moderate exercise and Vitamin D3 vs. Sedentary high-fat diet was evaluated on Adipose tissue SIRT1 protein (ng/mg protein) (p=<0.001). The combination of moderate swimming exercise and vitamin D3 supplementation significantly increased adipose tissue SIRT1 protein levels (23.38 vs 10.11 ng/mg, p<0.001) in high-fat diet-induced obese rats.
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