A novel device containing cephalexin as a model drug using a self-setting bioactive cement basing on CaOSiO2-P2O5 glass was investigated. Glass powders contained 5% cephalexin powder hardened within 5 min after being mixed with a phosphate buffer. After hardening, in vitro drug release from homogeneous or heterogeneous drug-loaded cement pellets in a simulated body fluid at pH 7.25 and 37°C continued for more than 2 weeks.
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Otsuka et al. (1992) studied this question.