Key result
Prothrombin complex concentrate therapy improved rapid achievement of target international normalized ratios and hemostasis compared to plasma, with a lower risk of fluid overload events.
Why the study?
Does prothrombin complex concentrate improve rapid anticoagulation reversal and hemostasis compared to plasma in patients on vitamin K antagonists requiring emergency surgery?
Systematic Review
Does prothrombin complex concentrate improve rapid anticoagulation reversal and hemostasis compared to plasma in patients on vitamin K antagonists requiring emergency surgery?
Prothrombin complex concentrate is superior to plasma for rapid INR reversal and hemostasis in patients on vitamin K antagonists requiring emergency surgery, supporting current guideline recommendations.
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Supports PCC over plasma for urgent VKA reversal in emergency surgery; reinforces guideline recommendations with Level 1 evidence.
Levy et al. (2018) conducted a systematic review in Vitamin K antagonist reversal in the perioperative setting. Prothrombin complex concentrate vs. Plasma was evaluated on Rapid reduction of international normalized ratio and bleeding control. Prothrombin complex concentrate therapy improved rapid achievement of target international normalized ratios and hemostasis compared to plasma, with a lower risk of fluid overload events.
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