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October 1, 1988Neurology

Treatment of Guillain‐Barre syndrome with high‐dose gammaglobulin

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Why the study?

Does high-dose intravenous gammaglobulin improve the clinical course in patients with severe Guillain-Barré syndrome?

Population

8 patients with severe Guillain-Barré syndrome (GBS)

Design

Case_series

Authors

RKR. P. KleywegErasmus University RotterdamFMF.G.A. van der MechéErasmus MCJMJan MeulsteeCanisius-Wilhelmina Ziekenhuis

Discussion

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Overview

Hypothesis-generating for IVIG in severe GBS; randomized trials needed before clinical adoption.

Structured PICO

Does high-dose intravenous gammaglobulin improve the clinical course in patients with severe Guillain-Barré syndrome?

P
Population
8 patients with severe Guillain-Barré syndrome (GBS)
I
Intervention
High-dose intravenous gammaglobulin (IVGG)
O
Outcome
Clinical course improvement

High-dose intravenous gammaglobulin may provide clinical benefit in severe Guillain-Barré syndrome, warranting further investigation in randomized trials.

Limitations

  • Not a randomized trial

Cite This Study

Kleyweg et al. (1988) studied this question.

synapsesocial.com/papers/6a86e8af48ef9afcd2a24c1ahttps://doi.org/10.1212/wnl.38.10.1639
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