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transgenerationally rather than a direct effect of the initial environmental exposure.However, fewer generations are required if the initial environmental exposure is limited to the paternal side or occurs before the formation of primordial germ cells on the maternal side.16 Hypertension December 2018mechanisms.29,30 For example, lncRNA Xist plays a key role in X chromosome inactivation.Accordingly, this review will cover studies of lncRNAs in hypertension but recognize that the mechanism underlying the physiological role of lncRNAs is not always clear and could involve both epigenetic and nonepigenetic actions.The reader is referred to other reviews for microRNAs' role in hypertension.31,32
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Mingyu Liang (2018) studied this question.
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