Retrospective cohort study reveals distinct morphology and favorable survival in gastric carcinoma with lymphoid stroma, suggesting the need for a separate tumor classification.
Key Points
To delineate the distinct gross and histologic characteristics of gastric carcinoma with lymphoid stroma and evaluate its prognostic implications.
Pathologic and clinical review of surgically resected gastric carcinomas (N=1041).
Histologic evaluation assessing tumor circumscription, stromal composition, inflammatory cell infiltration, and cancer cell nest patterns.
Carcinoma with lymphoid stroma was identified in 4% of surgically resected gastric carcinomas (42 of 1041 cases).
Gross pathology consistently revealed clear circumscription with central ulceration, alongside a nondesmoplastic stroma uniformly infiltrated by lymphocytes and plasma cells.
Patients with this subtype achieved a high post-surgical survival rate relative to typical gastric carcinoma outcomes.