Cu‐Catalyzed Coupling of O‐Acyl Oximes with Isatins: Domino Rearrangement Strategy for Direct Access to Quinoline‐4‐Carboxamides by C–N Bond Cleavage

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A mild domino rearrangement strategy for the direct access to substituted quinoline‐4‐carboxamides has been developed. This copper‐catalyzed coupling reaction of O ‐acyl oximes with isatins in the presence of molecular oxygen as the sole oxidizing agent proceeds through a ring expansion of the isatins through cleavage of the two C–N bonds.