Key result
Statin use was associated with a significant reduction in long-term mortality compared to non-users following open surgery for abdominal aortic aneurysms (RR 0.62; 95% CI 0.45-0.83).
Why the study?
Does statin use reduce early and long-term mortality in patients undergoing open surgery for abdominal aortic aneurysms?
Cohort (n=640)
No
Does statin use reduce early and long-term mortality in patients undergoing open surgery for abdominal aortic aneurysms?
Relative Risk: 0.62 (95% CI 0.45–0.83)
Statin use is associated with significantly reduced early and long-term mortality in patients undergoing open surgical repair of abdominal aortic aneurysms.
Supports routine lipid-lowering after open abdominal aortic aneurysm repair; leaves open whether this.
In this single center, retrospective cohort study we wished to compare early and total mortality for all patients treated for abdominal aortic aneurysms (AAA) with open surgery who were taking statins compared to those who were not. A cohort of 640 patients with AAA was treated with open surgery between 1999 and 2012. Patients were consecutively recruited from a source population of 390,000; 21.3% were female, and the median age was 73 years. The median follow-up was 3.93 years, with an interquartile range of 1.79-6.58 years. The total follow-up was 2855 patient-years. An explanatory strategy was used. The propensity score (PS) was implemented to control for selection bias and confounders. The crude effect of statin use showed a 78% reduction of the 30-day mortality. A stratified analysis using the Mantel-Haenszel method on quintiles of the PS gave an adjusted effect of the odds ratio equal to 0.43 (95% CI: 0.18-0.96), indicating a 57% reduction of the 30-day mortality for statin users. The adjusted rate ratio was 0.62 (95% CI: 0.45-0.83), indicating a reduction of long-term mortality of 38% for statin users compared to non-users for a median follow-up of 3.93 years. This retrospective cohort study showed a significant beneficial effect of statin use on early and long-term survival for patients treated with open surgery. To be conclusive, our results need to be replicated by a randomized clinical trial.
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Mathisen et al. (2017) conducted a cohort in Abdominal aortic aneurysms (AAA) (n=640). Statins vs. Non-users was evaluated on Long-term mortality (RR 0.62, 95% CI 0.45-0.83). Statin use was associated with a significant reduction in long-term mortality compared to non-users following open surgery for abdominal aortic aneurysms (RR 0.62; 95% CI 0.45-0.83).
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