Key result
Statin use linked to ~43% lower long-term mortality vs nonusers after AAA repair.
Why the study?
Does statin therapy improve survival and reduce perioperative cardiac complications in patients undergoing abdominal aortic aneurysm repair?
Meta-Analysis (n=28,496)
Does statin therapy improve survival and reduce perioperative cardiac complications in patients undergoing abdominal aortic aneurysm repair?
Hazard Ratio: 0.57 (95% CI 0.47–0.69)
Statin therapy is associated with significantly lower long-term and short-term mortality, as well as fewer perioperative cardiac complications, in patients undergoing AAA repair.
May support statin use after AAA repair; leaves open randomized confirmation of causality.
Background No consensus exists on the effect of statin therapy on survival after abdominal aortic aneurysm (AAA) repair. The objective of this review was to systematically review the literature to investigate whether statin therapy is associated with improved outcomes after AAA repair. Methods We searched PubMed, Embase, and Cochrane Library to find relevant randomized controlled trials and cohort studies. Outcomes of interest included long‐term mortality and short‐term mortality and perioperative cardiac complications. Results Nine cohort studies and one post hoc study of a randomized controlled trial were included, giving a total of 28,496 enrolled patients. Compared with nonusers of statins, statin use was associated with significantly lower long‐term mortality (HR 0.57, 95% CI 0.47–0.69, I2 = 70.1%), short‐term mortality (RR 0.60, 95% CI 0.38–0.98, I2 = 51.7%), and fewer perioperative cardiac complications (RR 0.46, 95% CI 0.26–0.80, I2 = 0%). Conclusions The results suggest that statin therapy has beneficial effects on survival after AAA repair and statins should be recommended to patients who will receive open or endovascular AAA repair. However, these findings mainly relied on data from cohort studies, and the high‐quality studies are still needed to further validate our conclusions.
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Huang et al. (2018) conducted a meta-analysis in Abdominal aortic aneurysm (AAA) repair (n=28,496). Statin therapy vs. Nonusers of statins was evaluated on Long-term mortality (HR 0.57, 95% CI 0.47-0.69). Statin use was associated with significantly lower long-term mortality compared with nonusers after abdominal aortic aneurysm repair (HR 0.57; 95% CI 0.47-0.69).
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