Why the study?
Although studies suggest statins may decrease AAA progression, rupture risk, and post-surgical mortality, a synthesis of human and animal evidence on potential mechanisms was needed.
Do statins decrease the progression and risk of rupture in abdominal aortic aneurysms?
Do statins decrease the progression and risk of rupture in abdominal aortic aneurysms?
This review highlights the potential of statins to slow the progression and reduce the rupture risk of abdominal aortic aneurysms through pleiotropic mechanisms.
Answers are grounded in this paper and cite their sources.
Supports statin consideration in AAA; leaves open need for RCTs to confirm growth and mortality effects.
Abdominal aortic aneurysm (AAA) is a prevalent condition which causes progressive growth and rupture of aortic wall with a high death rate. Several studies have found that treatment with statins may decrease the progress of AAA and the risk of rupture by suppressing the inflammatory mediators, decreasing oxidative stress, and inhibiting mechanisms involved in extracellular matrix (ECM) degradation. Moreover, some studies have reported that prehospital therapy with statins can decrease mortality after surgery. The novelty of this paper is that different studies including those performed in humans and animals were reviewed and the potential mechanisms by which statins can have an effect on AAA were summarized. Overall, the evidence suggested an association between treatment with statins and improvement of AAA.
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Hosseini et al. (2022) studied this question.
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