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April 1, 2011British journal of surgeryOpen Access

Systematic review and meta-analysis of the effects of statin therapy on abdominal aortic aneurysms (Br J Surg 2011; 98: 362–353)

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Key result

Statin therapy for attenuating abdominal aortic aneurysm growth remains controversial due to low-quality evidence, differing growth rate estimation methods, and misclassification bias.

Why the study?

Does statin therapy reduce AAA expansion in patients with abdominal aortic aneurysms?

Population

Patients with abdominal aortic aneurysms (AAA)

Comparison

Statin therapy vs Non-statin therapy

Design

Editorial

Authors

MBMarc A. BaileyLeeds General InfirmaryJDJonathan DunneImperial College Healthcare NHS TrustKGKathryn J GriffinUniversity of Leeds

Discussion

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Implication

This commentary emphasizes the need for consistent AAA growth measurement and rigorous control of statin misclassification bias before drawing conclusions on statins' efficacy in attenuating AAA growth.

Structured PICO

Does statin therapy reduce AAA expansion in patients with abdominal aortic aneurysms?

P
Population
Patients with abdominal aortic aneurysms (AAA)
I
Intervention
Statin therapy
C
Comparator
Non-statin therapy
O
Outcome
AAA growth attenuation/expansionsurrogate

This commentary emphasizes the need for consistent AAA growth measurement and rigorous control of statin misclassification bias before drawing conclusions on statins' efficacy in attenuating AAA growth.

Limitations

  • Differing methodologies of AAA growth rate estimation may introduce bias into the analysis.
  • Minimal effort to control for misclassification bias with regard to statin use in many of the studies.
  • Differing methodologies of AAA growth rate estimation
  • Minimal effort to control for misclassification bias with regard to statin use

Cite This Study

Bailey et al. (2011) conducted a letter in Abdominal aortic aneurysm. Statin therapy vs. Non-statin was evaluated on Abdominal aortic aneurysm growth attenuation. Statin therapy for attenuating abdominal aortic aneurysm growth remains controversial due to low-quality evidence, differing growth rate estimation methods, and misclassification bias.

synapsesocial.com/papers/6aa81f922496c47ffc876983https://doi.org/10.1002/bjs.7512

Topics

Statin therapy
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Efficacy of Pharmacotherapy for Decreasing the Expansion Rate of Abdominal Aortic Aneurysms: A Systematic Review and Meta-Analysis2008 · 78 citations
  2. 2Medical Management of Small Abdominal Aortic Aneurysms2008 · 346 citations
  3. 3Abdominal Aortic Aneurysm Expansion2004 · 691 citations
  4. 4A meta-analysis of clinical studies of statins for prevention of abdominal aortic aneurysm expansion2010 · 78 citations