Key result
Intraoperative liberal fluid therapy (>5 ml/Kg/hr) was associated with significantly increased postoperative morbidity compared to restrictive fluid management in advanced laparoscopic colorectal operations.
Why the study?
Optimal intraoperative fluid requirements in advanced laparoscopic colorectal operations remain unclear, with no consensus in the literature.
Does liberal intraoperative fluid therapy increase postoperative morbidity in patients undergoing advanced laparoscopic colorectal operations?
Cohort (n=201)
No
Does liberal intraoperative fluid therapy increase postoperative morbidity in patients undergoing advanced laparoscopic colorectal operations?
Absolute Event Rate: 45.2% vs 33.7%
p-value: p=0.03
Intra-operative liberal fluid management (>5 ml/Kg/hr) is associated with increased postoperative morbidity compared to restrictive fluid management in advanced laparoscopic colorectal resections.
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Supports restrictive fluids in laparoscopic colorectal surgery; hypothesis-generating and requires randomized confirmation.
Avula et al. (2020) conducted a cohort in Colorectal cancer (n=201). Liberal intraoperative fluid regimen (> 5 ml/Kg/hr) vs. Restrictive fluid regimen (<= 5 ml/Kg/hr) was evaluated on Postoperative morbidity (Clavien-Dindo classification 1-5) (p=0.03). Intraoperative liberal fluid therapy (>5 ml/Kg/hr) was associated with significantly increased postoperative morbidity compared to restrictive fluid management in advanced laparoscopic colorectal operations.
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