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November 1, 1985Acta Anaesthesiologica Scandinavica

A Controlled Study on the Effect of Epidural Analgesia with Local Anaesthetics and Morphine on Morbidity after Abdominal Surgery

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Why the study?

Does combined general anaesthesia and epidural analgesia reduce postoperative morbidity and improve pain control compared to general anaesthesia and systemic morphine in patients undergoing elective abdominal surgery?

Population

100 patients scheduled for elective abdominal surgery

Comparison

Combined general anaesthesia and epidural… vs General anaesthesia and systemic morphine for…

Design

RCT, randomized

Follow-up

postoperative period

Authors

NHN. C. HjortsøAvenue Day HospitalPNPeter NeumannTufts Medical CenterFFF. FrøsigRigshospitalet

Discussion

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Overview

Epidural analgesia improves pain without reducing morbidity after abdominal surgery; challenges assumptions that superior analgesia alone decreases complications.

Structured PICO

Does combined general anaesthesia and epidural analgesia reduce postoperative morbidity and improve pain control compared to general anaesthesia and systemic morphine in patients undergoing elective abdominal surgery?

P
Population
100 patients scheduled for elective abdominal surgery
I
Intervention
Combined general anaesthesia and epidural analgesia with etidocaine 1.5% intraoperatively (T4-S5) and bupivacaine 0.5% 5 ml/4 h for 24 h and morphine 4 mg/12 h for 72 h, with no prophylactic antithrombotic treatment
C
Comparator
General anaesthesia (low-dose fentanyl) and systemic morphine for postoperative pain, with low-dose heparin
O
Outcome
Postoperative morbidity and postoperative paincomposite

Epidural analgesia provides superior pain relief but does not reduce postoperative morbidity compared to systemic morphine after major abdominal surgery.

Cite This Study

Hjortsø et al. (1985) studied this question.

synapsesocial.com/papers/6a86edbf4a47ef1dc7d3bae5https://doi.org/10.1111/j.1399-6576.1985.tb02302.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Intramuscular and Epidural Morphine for Postoperative Analgesia in the Grossly Obese1984 · 183 citations
  2. 2Epidural analgesia improves postoperative nitrogen balance.1978 · 167 citations
  3. 3Epidural Versus General Anaesthesia for Total Hip Arthroplasty in Elderly Patients1980 · 229 citations
  4. 4Postoperative Analgesia and Lung Function: a Comparison of Intramuscular with Epidural Morphine1982 · 46 citations
  5. 5Postoperative fatigue and changes in nutritional status1984 · 74 citations