Key result
A theoretical model of calcium-dependent channel activity predicts global calcium oscillations and their entrainment to oscillatory electric or mechanical fields in beating cardiomyocytes.
A new theoretical model explains the physics of spontaneous calcium oscillations and their entrainment in cardiac cells using a few physically relevant parameters.
Offers a theoretical basis for calcium oscillations in cardiomyocytes; leaves open entrainment by external fields pending experimental validation.
Mechanical contraction in muscle cells requires Ca to allow myosin binding to actin. Beating cardiomyocytes contain internal Ca stores whose cytoplasmic concentration oscillates. Our theory explains observed single channel dynamics as well as cellular oscillations in spontaneously beating cardiomyocytes. The Ca dependence of channel activity responsible for Ca release includes positive feedback with a delayed response. We use this to predict a dynamical equation for global calcium oscillations with only a few physically relevant parameters. The theory accounts for the observed entrainment of beating to an oscillatory electric or mechanical field.
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Cohen et al. (2019) studied Spontaneous calcium oscillations in cardiac cells. Theoretical model of calcium oscillations was evaluated on Global calcium oscillations and entrainment. A theoretical model of calcium-dependent channel activity predicts global calcium oscillations and their entrainment to oscillatory electric or mechanical fields in beating cardiomyocytes.
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