Population
Rat model of pressure overload-induced cardiac hypertrophy (50-80% hypertrophy) and control rats
Comparison
Pressure overload-induced cardiac hypertrophy vs Control rats
Design
Preclinical
Authors
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No immediate clinical implications from rat data; hypothesis-generating for ryanodine receptor density in human hypertrophy.
Severe cardiac hypertrophy in rats is associated with a decreased density of sarcoplasmic reticulum ryanodine receptors, which may contribute to altered calcium handling.
Naudin et al. (1991) studied this question.
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