Population
Rat hearts with pressure overload-induced hypertrophy (via aortic stenosis) and sham-operated controls
Comparison
Pressure overload (aortic stenosis) vs Sham-operated animals
Design
Preclinical
Follow-up
5 days
Authors
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Indicates compensatory Ca2+ channel upregulation in hypertrophy; leaves open relevance to human disease or therapy.
Pressure overload induces an adaptational increase in the total number of cardiac Ca2+ channels without altering their affinity or inotropic responsiveness.
Mayoux et al. (1988) studied this question.
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