Key result
Calcium channel blockers reduce serum-stimulated cardiomyocyte hypertrophy in cell culture models.
Why the study?
Does modulation of calcium influx through the L-type Ca2+ channel affect cardiomyocyte hypertrophy in cell culture models?
Does modulation of calcium influx through the L-type Ca2+ channel affect cardiomyocyte hypertrophy in cell culture models?
Modulation of calcium influx through L-type Ca2+ channels directly affects cardiomyocyte hypertrophy in vitro, providing a mechanistic basis for the efficacy of calcium channel blockers in treating myocardial hypertrophy.
Authors
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In vitro CCB effects on hypertrophy should not change practice; leaves open in vivo validation and clinical translation.
Lubic et al. (1995) studied Myocardial hypertrophy. Calcium channel blockers (verapamil, nifedipine) and other agents altering calcium influx vs. Control (serum-stimulated or spontaneously contracting cells) was evaluated on Cardiomyocyte hypertrophy. Calcium channel blockers, including verapamil and nifedipine, significantly reduced serum-stimulated cardiomyocyte hypertrophy in cell culture models.
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