Population
Human coronary smooth muscle cells (cSMC)
Comparison
1,4-DHP agonist or antagonist vs Control (untreated cells or cells without DHPs)
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Suggests L-type Ca channel mechanism in coronary SMC proliferation; hypothesis-generating for CCB antiatherosclerotic effects.
Dihydropyridine-sensitive L-type calcium channels modulate calcium influx and proliferative activity in human coronary smooth muscle cells, providing a potential mechanism for their antiatherosclerotic effects.
Kruse et al. (1994) studied this question.
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