Key result
Dihydropyridine calcium channel modulators modify cardiac sodium channels in rat cells, suggesting sodium-calcium channel homology.
Why the study?
It was unclear whether cardiac sodium channels possess dihydropyridine receptors similar to those on calcium channels.
Population
Cultured ventricular cells of neonatal rats
Comparison
Effects of DHP enantiomers PN200-110, BAY-K 8644, and racemic nitrendipine on sodium channels
Design
Preclinical electrophysiological study using patch-clamp method
Authors
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Should not alter clinical use of dihydropyridines; leaves open channel homology for targeted research.
Dihydropyridine calcium channel modulators exert stereospecific effects on cardiac sodium channels, suggesting homology between sodium and calcium channels.
Yatani et al. (1988) studied this question. Dihydropyridine (DHP) calcium channel modulators (PN200-110, BAY-K 8644, nitrendipine) was evaluated on Cardiac sodium whole cell and single-channel currents. Dihydropyridine calcium channel modulators stereospecifically modified cardiac sodium channels in cultured neonatal rat ventricular cells, suggesting homology between sodium and calcium channels.
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