Why the study?
Do dihydropyridine calcium channel modulators affect calcium influx and proliferation in human coronary smooth muscle cells?
Population
Human coronary smooth muscle cells (cSMC)
Comparison
Dihydropyridine calcium channel agonist or… vs Medium without DHPs
Design
Preclinical
Follow-up
Up to 24 hours
Authors
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L-type channel modulation of VSMC proliferation in animal cells; leaves open antiatherosclerotic effects of dihydropyridines in patients.
Do dihydropyridine calcium channel modulators affect calcium influx and proliferation in human coronary smooth muscle cells?
L-type calcium channels modulate angiotensin II- and serum-induced calcium influx and proliferation in human coronary smooth muscle cells, providing a potential mechanism for the antiatherosclerotic properties of dihydropyridine calcium channel blockers.
Kruse et al. (1994) studied this question.
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