Why the study?
Risk factors for stress-induced hyperglycemia in patients without diabetes after cardiac surgery required systematic evaluation.
Do specific clinical and procedural risk factors increase the risk of postoperative stress hyperglycemia in patients without diabetes following cardiac surgery?
Comparison
Presence vs absence of clinical and procedural risk factors
Design
Systematic review and meta-analysis of 8 case-control and 3 cohort studies
Key result
Age >65 years (OR 3.47) and cardiopulmonary bypass time >2 hours (OR 20.26) were identified as major risk factors for postoperative stress hyperglycemia in patients without diabetes following cardiac surgery.
Authors
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May identify high-risk non-diabetic patients after cardiac surgery; leaves open prospective validation before guiding practice.
Systematic Review (n=11,645)
Do specific clinical and procedural risk factors increase the risk of postoperative stress hyperglycemia in patients without diabetes following cardiac surgery?
Odds Ratio: 3.47 (95% CI 2.61–4.32)
p-value: p=<0.00001
In non-diabetic patients undergoing cardiac surgery, prolonged cardiopulmonary bypass time, advanced age, and combined surgical procedures are major risk factors for developing postoperative stress hyperglycemia.
Zhang et al. (2025) conducted a systematic review in Postoperative stress hyperglycemia (n=11,645). Age >65 years vs. Age ≤65 years was evaluated on Postoperative stress hyperglycemia (OR 3.47, 95% CI 2.61-4.32, p=<0.00001). Age >65 years (OR 3.47) and cardiopulmonary bypass time >2 hours (OR 20.26) were identified as major risk factors for postoperative stress hyperglycemia in patients without diabetes following cardiac surgery.