Key result
Intrathecal administration of 10 µg sufentanil combined with 50 mg hyperbaric lignocaine significantly increased the duration of complete analgesia compared to lignocaine alone (80.8 vs 66.04 minutes, p<0.01).
RCT (n=100)
Single-blind
Randomized
No
Absolute Event Rate: 80.8% vs 66.04%
p-value: p=< 0.01
May extend analgesia in spinal anesthesia; leaves open need for larger RCTs on safety and dosing.
Spinal anaesthesia with hyperbaric lignocaine has the limitation of relatively shorter duration of action, which means that early analgesic intervention is needed in the postoperative period. Intrathecal opioid administration has a promising role in fulfilling this objective. Sufentanil, the congener of fentanyl is 1000 more times potent than morphine is a newer addition to the armoury of modern day anaesthesiologists.
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Madhala et al. (2016) conducted an RCT in Perianal surgeries (n=100). Sufentanil and lignocaine combination vs. 5% hyperbaric lignocaine 50 mg was evaluated on Duration of complete analgesia (minutes) (p=< 0.01). Intrathecal administration of 10 µg sufentanil combined with 50 mg hyperbaric lignocaine significantly increased the duration of complete analgesia compared to lignocaine alone (80.8 vs 66.04 minutes, p<0.01).
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