Key result
Moderate hyperventilation significantly increased EEG seizure duration during the first electroconvulsive therapy treatment compared with normal ventilation (P < 0.05).
Why the study?
Does moderate hyperventilation prolong EEG seizure duration in patients undergoing electroconvulsive therapy?
Population
19 patients undergoing electroconvulsive therapy (ECT)
Comparison
Moderate hyperventilation with end-tidal… vs Normal ventilation with ETCO2 of 40 mm Hg during…
Design
RCT, randomized, double-blind
Follow-up
after 6 sequential ECT treatments
Authors
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May support moderate hyperventilation in initial ECT to optimize seizures; extends RCT evidence on safe augmentation strategies.
RCT (n=19)
Double-blind
randomized
Does moderate hyperventilation prolong EEG seizure duration in patients undergoing electroconvulsive therapy?
p-value: p=<0.05
Moderate hyperventilation significantly prolongs EEG seizure duration during the first electroconvulsive therapy session without increasing adverse effects.
Sawayama et al. (2008) conducted an RCT in Patients undergoing electroconvulsive therapy (n=19). Moderate hyperventilation vs. Normal ventilation (ETCO2 of 40 mm Hg) was evaluated on EEG seizure duration in the first treatment (p=<0.05). Moderate hyperventilation significantly increased EEG seizure duration during the first electroconvulsive therapy treatment compared with normal ventilation (P < 0.05).
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