Key result
Elevated HbA1c ≥6.1% was an independent risk factor for left atrial thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation.
Why the study?
Does elevated HbA1c increase the risk of left atrial thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation?
Observational (n=1,158)
Yes
Does elevated HbA1c increase the risk of left atrial thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation?
Answers are grounded in this paper and cite their sources.
Elevated HbA1c (≥6.1%) is an independent predictor of left atrial thrombus and spontaneous echo contrast in patients with non-valvular atrial fibrillation, suggesting it may serve as a marker for a prothrombotic state.
OBJECTIVES: To evaluate the relationship between hemoglobin A1c (HbA1c) and risk of left atrial thrombus/spontaneous echo contrast (LAT/SEC) in non-valvular atrial fibrillation (AF) patients. METHODS: In this retrospective study, 1158 consecutive non-valvular AF patients undergoing transesophageal echocardiography prior to radiofrequency catheter ablation or electric cardioversion were enrolled. Baseline characteristics were collected and analyzed. RESULTS: There were 87 (7.5%) patients with LAT/SEC. The HbA1c levels in the patients with LAT/SEC were significantly higher than that in patients without LAT/SEC (6.13 ± 0.41 vs. 5.89 ± 0.45 μmol/L, P < 0.001). The optimal cut-off point for HbA1c predicting LAT/SEC was 6.1% determined by receiver-operating characteristic curve. The area under the curve is 0.788 (95% confidence interval: 0.764-0.812). HbA1c ≥6.1% was an independent risk factor for LAT/SEC (odds ratio, 1.74; 95% confidence interval, 1.01-2.98; P = 0.045). CONCLUSIONS: Elevated HbA1c indicated a significantly increased risk for LAT/SEC in non-valvular AF patients. HbA1c might have significance in predicting the risk for prothrombotic state in non-valvular AF patients.
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Kuang et al. (2017) conducted an observational in Non-valvular atrial fibrillation (n=1,158). Elevated HbA1c (≥6.1%) vs. HbA1c <6.1% was evaluated on Left atrial thrombus or spontaneous echo contrast (LAT/SEC) (OR 1.74, 95% CI 1.01-2.98, p=0.045). Elevated HbA1c ≥6.1% was an independent risk factor for left atrial thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation.
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