Key result
Post-menopausal women exhibited a significantly higher pressor response and decreased total vascular conductance during passive ankle dorsiflexion compared to pre-menopausal women.
Why the study?
Does menopausal status affect the cardiovascular pressor response mediated by group III mechanoreceptors during passive ankle dorsiflexion in healthy women?
Observational (n=20)
Does menopausal status affect the cardiovascular pressor response mediated by group III mechanoreceptors during passive ankle dorsiflexion in healthy women?
Post-menopausal women exhibit an excessive pressor response to mechanoreflex activation, primarily driven by peripheral vasoconstriction, suggesting a loss of estrogen-mediated attenuation.
May indicate heightened mechanoreflex sensitivity post-menopause; hypothesis-generating and requires prospective studies before clinical relevance.
PURPOSE: We investigated the effects of group III mechanoreceptors to cardiovascular responses in both pre-menopausal woman and post-menopausal woman during passive ankle dorsiflexion (PAD). METHODS: Twenty healthy volunteers (10 post-menopausal women and 10 pre-menopausal women) were recruited for this study. Stroke volume (SV), heart rate (HR), cardiac output (CO), and total vascular conductances (TVC) were measured continuously throughout the experiment. To stimulate the group III mechanoreceptors, PAD was performed for one minute. RESULTS: The results showed that mean arterial pressure (MAP) mediated by the mechanoreflex activation was significantly increased in both groups. However, this pressor response was significantly higher in post-menopausal women. This reflex significantly increased both SV and CO in pre-menopausal women, while there were no differences in post-menopausal women. There was no difference in HR in either group. The mechanoreflex significantly decreased TVC in post-menopausal woman, while there was no difference in pre-menopausal woman. CONCLUSION: The results indicate that the excessive pressor response mediated by the mechanoreflex occurs due to overactivity of group III mechanorecptors and the mechanism is produced mainly via peripheral vasoconstriction in post-menopausal women.
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Park et al. (2011) conducted an observational in Healthy volunteers (n=20). Post-menopausal status vs. Pre-menopausal status was evaluated on Mean arterial pressure (MAP) response to passive ankle dorsiflexion. Post-menopausal women exhibited a significantly higher pressor response and decreased total vascular conductance during passive ankle dorsiflexion compared to pre-menopausal women.
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