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AY-9944, SKF 525-A, triparanol, and 22,25-diazacholestanol, agents known to inhibit hepatic cholesterol synthesis, suppressed the incorporation of acetate-[2-14C] and mevalonate-[3H] into cholesterol by sections of everted rat intestines. Clofibrate had no effect on the conversion of acetate-[2-14C] into cholesterol. The results indicate the presence in rat intestine of enzyme systems involved in the saturation of the Δ24-bond in lanosterol and its metabolites, the conversion of 7-dehydrocholesterol into cholesterol, and those inhibited by SKF 525-A. Hence, the pathway of intestinal cholesterol synthesis is similar to that of the liver.
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Cayen et al. (1968) studied this question.
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