Key result
Inhalation of 2% delta 9-THC marihuana induced orthostatic hypotension within 10 minutes in all 3 male glaucoma subjects, driven by peripheral venodilation.
Why the study?
Does delta 9-THC inhalation cause orthostatic hypotension in male glaucoma subjects?
Case Report (n=3)
Does delta 9-THC inhalation cause orthostatic hypotension in male glaucoma subjects?
Inhalation of 2% delta 9-THC can cause precipitous orthostatic hypotension driven by peripheral venodilation, occurring without compensatory tachycardia.
Delta-9-THC inhalation may precipitate orthostatic hypotension in glaucoma patients; case report leaves open generalizability and need for controlled studies.
3 male glaucoma subjects experienced orthostatic hypotension within 10 min after completing 2% delta 9-THC ranging from 57 to 233 ng/ml were found 5 min after smoking. Peripheral venodilation appeared responsible for the precipitous decrease in systolic blood pressure in all 3 subjects. These orthostatic episodes which clinically simulated the typical 'faint' were characterized by the absence of tachycardia and their relief by assuming a reclining position. The postural hypotension occurred despite differences in inhalation technique, level of delta (9)-THC present in plasma, previous marihuana experience of body habitus.
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Merritta et al. (2009) conducted a case report in Glaucoma (n=3). 2% delta 9-THC marihuana inhalation was evaluated on Orthostatic hypotension. Inhalation of 2% delta 9-THC marihuana induced orthostatic hypotension within 10 minutes in all 3 male glaucoma subjects, driven by peripheral venodilation.