Sensitivity to Compound G-4 ("Dichlo-Rophene") in Dentifrices

Compound G-4, also known as "dichlorophene," has been reported as being a potent fungicide and bactericide. This compound has been advocated for use not only in dentifrices but also in antiperspirant creams, deodorant creams, powders, toilet waters, and various preparations for combating dermatophytosis of the foot. Chemically, compound G-4 is dihydroxydichlordiphenylmethane with the following complete formulas: bis (5-chloro-2-hydroxyphenyl) methane; 2,2′-methylenebis (4-chlorophenol); or 2,2′-dihydroxy-5,5′-dichlorodiphenylmethane. Compound G-4 must not be confused with compound G-ll, which is known variously as AT-7 and K-34 and is the hexachlorophene compound used in dial® soap and some pHisoderm® (a detergent cream composed of sulfonated ether, petroleum, lactic acid, and wool fat cholesterols) preparations. Skin tests were first reported on 194 men and women using a petrolatum ointment containing 4% compound G-4. Of these, 191 had negative tests and 3 had positive tests. The three persons with positive tests showed only mild erythema. Another group of 37