Key result
Proton-pump inhibitor prophylaxis decreases the rate of upper gastrointestinal bleeding in patients receiving aspirin or clopidogrel, and is recommended for those with a history of ulceration.
Why the study?
Does proton-pump inhibitor prophylaxis reduce the risk of upper gastrointestinal bleeding in patients receiving antiplatelet therapy with aspirin and/or clopidogrel?
Population
Patients requiring antiplatelet therapy, including those with acute coronary syndrome, post-percutaneous…
Design
Review
Authors
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Supports PPI prophylaxis in high-risk antiplatelet users; leaves open optimal duration and net benefit in contemporary cohorts.
Does proton-pump inhibitor prophylaxis reduce the risk of upper gastrointestinal bleeding in patients receiving antiplatelet therapy with aspirin and/or clopidogrel?
Proton-pump inhibitor prophylaxis is a useful precaution to reduce upper gastrointestinal bleeding in patients requiring antiplatelet therapy, especially those with a history of UGI ulceration or bleeding.
Liberopoulos et al. (2005) conducted a review in Upper gastrointestinal hemorrhage risk in patients on antiplatelet therapy. Proton-pump inhibitors was evaluated. Proton-pump inhibitor prophylaxis decreases the rate of upper gastrointestinal bleeding in patients receiving aspirin or clopidogrel, and is recommended for those with a history of ulceration.
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