Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
No takes yet. Share an insight, caveat, or question.
Ahn et al. (2006) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: