Key result
KirBac1.1 reconstituted in liposomes generates a K+-selective permeation path that is inhibited by extraliposomal Ba2+, Ca2+ ions, and acid (pKa approximately 6).
Population
KirBac1.1 (prokaryotic inward rectifying K+ channel) reconstituted in liposomes
Comparison
86Rb+ uptake assay and exposure to… vs KcsA (acid-activated bacterial potassium channel)
Design
Preclinical
Authors
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No direct clinical implications; leaves open whether KirBac1.1 properties translate to mammalian cardiac channels.
This study provides the first functional characterization of the prokaryotic Kir channel KirBac1.1, establishing its ion selectivity and inhibition profile.
Enkvetchakul et al. (2004) studied this question. KirBac1.1 reconstituted in liposomes vs. KcsA was evaluated on K+-selective permeation and inhibition by extraliposomal ions and acid. KirBac1.1 reconstituted in liposomes generates a K+-selective permeation path that is inhibited by extraliposomal Ba2+, Ca2+ ions, and acid (pKa approximately 6).
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