A transition metal catalyst can trigger the cycloaromatization of an enediyne. A coordinatively unsaturated rhodium complex catalyzes the cyclization of the acyclic enediyne 1 to produce 3. The cyclization, which is similar to the Myers reaction, proceeds via a vinylidene–rhodium intermediate and the 1,4-organorhodium diradical 2. Rh = [RhCl(iPr3P)2].
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Ohe et al. (1996) studied this question.
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