The discovery of new chemical transformations permits exploration and development of novel synthesis strategies. This account describes the invention of endo-selective cycloisomerizations of alkynyl alcohols, and mechanistically related transformations of terminal alkynes tethered to nitrogen, carbon, and sulfur nucleophiles (see diagram). The synthetic utility of these new transformations is exemplified in applications to anti-AIDS nucleosides, polycyclic ethers, and oligosaccharides.
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Frank E. McDonald (1999) studied this question.