Answers are grounded in this paper and cite their sources.
Marine engineering: A modular strategy featuring an intramolecular 1,4-addition/aldol/dehydration cascade sequence (see scheme; TBS=tert-butyldimethylsilyl) has enabled the total synthesis of cortistatin A, a potent anti-angiogenic marine natural product. This flexible route offers access to other members of the cortistatin family, both natural and designed.
No takes yet. Share an insight, caveat, or question.
Nicolaou et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: