Key result
Patients experiencing thromboembolic complications after neurointervention exhibited significantly higher aspirin resistance (630 vs 468.5 ARU, p=0.003) and lower clopidogrel platelet inhibition (23% vs 35%, p=0.010) than those without complications.
Why the study?
Does antiplatelet drug resistance predict thromboembolic complications in patients undergoing neurointervention?
Cohort (n=53)
No
Does antiplatelet drug resistance predict thromboembolic complications in patients undergoing neurointervention?
Absolute Event Rate: 630% vs 468.5%
p-value: p=0.003
Resistance to both aspirin and clopidogrel is significantly associated with the occurrence of thromboembolic complications following neurointerventional procedures.
Authors
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Antiplatelet resistance was associated with thromboembolic complications after neurointervention; hypothesis-generating and requires prospective validation before guiding therapy.
Ryu et al. (2010) conducted a cohort in Cerebrovascular disease requiring neurointervention (n=53). Thromboembolic complications vs. No thromboembolic complications was evaluated on Aspirin resistance level (ARU) (p=0.003). Patients experiencing thromboembolic complications after neurointervention exhibited significantly higher aspirin resistance (630 vs 468.5 ARU, p=0.003) and lower clopidogrel platelet inhibition (23% vs 35%, p=0.010) than those without complications.
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