June 12, 2000Archives of Internal Medicine
Update on Antiplatelet Therapy for Stroke Prevention
Why the study?
Does the combination of low-dose aspirin and extended-release dipyridamole prevent recurrent stroke in patients with prior TIA or stroke compared to either drug alone?
Population
Patients suffering from a transient ischemic attack (TIA) or stroke
Comparison
Antiplatelet therapy, specifically the… vs Either drug alone (aspirin or dipyridamole)
Design
Review
Authors
Discussion
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Member takes
Implication
Supports aspirin-dipyridamole for secondary stroke prevention; leaves open need for contemporary randomized comparisons.
Structured PICO
Does the combination of low-dose aspirin and extended-release dipyridamole prevent recurrent stroke in patients with prior TIA or stroke compared to either drug alone?
P
Population
Patients suffering from a transient ischemic attack (TIA) or stroke
I
Intervention
Antiplatelet therapy, specifically the combination of low-dose aspirin plus extended-release dipyridamole
C
Comparator
Either drug alone (aspirin or dipyridamole)
O
Outcome
Stroke recurrencehard clinical
The combination of low-dose aspirin and extended-release dipyridamole is an effective first-line antiplatelet therapy for preventing recurrent stroke in patients with prior TIA or stroke.
Cite This Study
Sacco et al. (2000) studied this question.