New Sesquiterpenoids from Clary Sage Oil (Salvia sclarea L.)

Six sesquiterpenoids, ( R , 5 E )‐2, 12‐epoxycaryophyll‐5‐ene (1) , (2 R , 5 E )‐caryophyll‐5‐en‐12‐al (2) , (2 S , 5 E )‐caryophyll‐5‐en‐12‐al (3) , isospathulenol (4) , (1 R , 5 R )‐ 1,5‐epoxysalvial‐4(14)‐ene (5) , and salvial‐4(14)‐en‐l‐one (6) have been identified for the first time in clary sage oil ( Salvia sclarea L.). The structures and absolute configurations of 1–6 are corroborated by partial syntheses and their organoleptic properties are discussed. The compounds 5, 6 and mintsulfide (14) possess the rare C‐skeleton C , for which the semisystematic name ‘salvialane’ is proposed. The sesquiterpenoids 1–5 are new.