Antiproliferative alkaloid: Cortistatin A is a high-affinity ligand for a small set of protein kinases including Rho-associated, coiled-coil-containing protein kinase (ROCK), cyclin-dependent kinase 8 (CDK8), and cyclin-dependent kinase 11 (CDK11). Models of cortistatin A bound to a crystallographic structure of ROCK (see picture) and a homology model of CDK8 are presented.
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Cee et al. (2009) studied this question.
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